On January 13th, we held a short workshop at the Swiss-Prot group in Geneva:

1st part by Holger Scheib

Holger showed the exciting use of both the iMolTalk server and a structure viewer DeepView? in a side-by-side manner for the analysis of the effects of mutations on the interface between domains in p53.

read more here: [iMolTalk_Workshop_HS.pdf]

contact: holger@moltalk.org

2nd part by Alexander Diemand

Alex has chosen to work on aspartate aminotransferases for several reasons:

- huge enough to get confused: around 400 amino acids per chain

- homodimer

- quite an interesting interface between the dimers

- cross interactions of residues with the other chain's active site

- covalently bound co-factor

- substrate binding implicates domain movement

read more here: [iMolTalk_Workshop_AVD.pdf]

contact: axeld@moltalk.org

On March 16th, a workshop was given that focused on the scripting capabilities of MolTalk

MolTalk scripting on the iMolTalk server

Some introductory material:

[iMolTalk_Workshop-II.pdf]

Then the practice:

[iMolTalk_Workshop-II_Example.pdf]

You can try yourself the scripts from the CodeRepository.